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Proceedings Paper

Near-infrared spectroscopic investigations of oxygenation changes related to brain activation
Author(s): Wemara Lichty; Kaoru Sakatania; Fang Lin; Pei Sun; Haishu Ding; Feng Wang
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Paper Abstract

Various NIRS studies have evaluated brain activity with intriguing and promising results. In this paper, results of an experiment using NIRS to evaluate brain activation induced by mental subtraction are discussed. The investigation evaluates activation responses of three NIR parameters, oxygenated- hemoglobin (Oxy-Hb), deoxygenated-Hb (Deoxy-Hb), and total-Hb (Tot-Hb). NIRS parameters were sensitive to mental subtraction; however, they were not sensitive to subtle variations in task difficulty. An important result was that order of presentation was significant, with activity during the first task being far greater than during the second task. Such findings raise questions about how to design cognitive studies using multiple task approaches commonly applied in brain activation research. A second topic addresses in this research was how to reduce brain activity during recovery. During nontask interval, subjects either rested or counted, which was used to reduce post-task mental activity. The nontask interval before mental subtraction (interval #1) was always lower than that of the two nontask intervals that followed cognitive performance (intervals #2 and 3). Recovery after activation was incomplete, regardless of type of nontask procedure. This suggests that recovery is still an issue needing elucidation and consideration in future designs.

Paper Details

Date Published: 17 September 1999
PDF: 5 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364388
Show Author Affiliations
Wemara Lichty, Tsinghua Univ. (United States)
Kaoru Sakatania, Tsinghua Univ. (China) and China-Japan Friendship Hospital (China)
Fang Lin, Tsinghua Univ. (China)
Pei Sun, Institute of Psychology (China)
Haishu Ding, Tsinghua Univ. (China)
Feng Wang, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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