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Proceedings Paper

Quantifying tissue hemodynamics by NIRS versus DOT: global versus focal changes in cerebral hemodynamics
Author(s): David A. Boas; Xuefeng Cheng; John A. Marota; Joseph B. Mandeville
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Paper Abstract

Near infrared spectroscopy (NIRS) is used to quantify changes in oxy-hemoglobin (HbO) and deoxy-hemoglobin (Hb) concentrations in tissue. The analysis uses the modified Beer-Lambert law, which is generally valid for quantifying global concentration changes. We examine the errors that result from analyzing focal changes in HbO and Hb concentrations. We find that the measured focal change in HbO and Hb are linearly proportional to the actual focal changes but that the proportionally constants are different. Thus relative changes in HbO and Hb cannot, in general, be quantified. However, we show that under certain circumstances it is possible to quantify these relative changes. This builds the case for diffuse optical tomography (DOT) which in general should be able to quantify focal changes in HbO and Hb through the use of image reconstruction algorithms that deconvolve the photon diffusion point-spread-function. We demonstrate the differences between NIRS and DOT using a rat model of somatosensory stimulation.

Paper Details

Date Published: 17 September 1999
PDF: 14 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364369
Show Author Affiliations
David A. Boas, Massachusetts General Hospital (USA), Harvard Medical School (USA), and Tufts Univ. (United States)
Xuefeng Cheng, Tufts Univ. (United States)
John A. Marota, Massachusetts General Hospital (USA) and Harvard Medical School (United States)
Joseph B. Mandeville, Massachusetts General Hospital (USA) and Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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