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Proceedings Paper

FCLA-assisted photodynamic diagnosis
Author(s): Yonghong He; Yonghong Tang; Shici Tan; Da Xing
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Paper Abstract

Conventional Photo-Dynamic Diagnosis has several serious limitations, such as autofluorescence disturbance, poor penetration ability of the exciting laser etc. All these problems are because the exciting laser wavelength at the main absorption peak of the photosensitizer (e.g. HpD) is too short. But to our knowledge, long wavelength He-Ne laser can sensitize appropriate sensitizer to produce singlet oxygen (1O2) without autofluorescence of the normal tissues. The 1O2 can react with FCLA (5-Fluoresceinyl Cypridina Luminescent Analog) to emit chemiluminescence at the peak wavelength 532 nm, thus we can use a high sensitivity detector to image the emission from FCLA to make a localization of the cancer. This is a novel idea proposed by our group, and its feasibility was proved by our experiments.

Paper Details

Date Published: 17 September 1999
PDF: 5 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364345
Show Author Affiliations
Yonghong He, South China Normal Univ. (China)
Yonghong Tang, South China Normal Univ. (China)
Shici Tan, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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