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Proceedings Paper

Photomodification of sensitizers commonly used in photosensitized tumor therapy
Author(s): Ricardas Rotomskis; Saulius Bagdonas; Petras Juzenas; Dimitry Y. Frolov; Giedre Streckyte
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Paper Abstract

Photostability studies of porphyrin-type sensitizers performed in aqueous solutions, model systems (sensitizers bound to human serum albumin or in a suspension of released erythrocyte ghosts) and in tumor tissue reveal that similar photomodification takes place in all investigated environments: photobleaching during exposure to light is followed by the formation of red-absorbing photoproducts. Photoproducts are not formed in the solutions of the less photostable sensitizer chlorin e6 and the most photostable sensitizer aluminum phthalocyanine tetrasulphonate. Interaction with photooxidizable biomolecules increases the photobleaching rate of porphyrin-type sensitizers. This should be taken into account in the estimation of optimal photodynamic doses. The modified formula including photodestruction of sensitizer and formation of photoproduct is suggested.

Paper Details

Date Published: 17 September 1999
PDF: 7 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364344
Show Author Affiliations
Ricardas Rotomskis, Vilnius Univ. (Lithuania)
Saulius Bagdonas, Vilnius Univ. (Lithuania)
Petras Juzenas, Vilnius Univ. (Norway)
Dimitry Y. Frolov, Vilnius Univ. (United States)
Giedre Streckyte, Vilnius Univ. (Lithuania)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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