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Proceedings Paper

Optically programmable assembly of ordered bead arrays: a novel technology for on-chip biochemical analysis
Author(s): Chiu Chau; Sukanta Banerjee; Michael Seul
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Paper Abstract

We describe an optically programmable bead array assembly process and its efficient implementation. Invoking our core technology of light-controlled electrokinetic assembly of particles near surfaces, this process enables the on-demand assembly and real-time manipulation of planar arrays of microparticles (`beads') within a small reaction chamber in response to electric fields and in accordance with computer- generated patterns of illumination. We are integrating this array fabrication process with proprietary microfluidics and image acquisition in a palmtop bioanalytical microlab to provide a general-purpose platform for a highly parallel assay format in which tens to thousands of biochemical tests (`assays') can be performed simultaneously on the surface of a semiconductor chip. Applications include the quantitative analysis of protein-protein interactions and DNA hybridization as well as cellular analysis.

Paper Details

Date Published: 19 August 1999
PDF: 7 pages
Proc. SPIE 3877, Microfluidic Devices and Systems II, (19 August 1999); doi: 10.1117/12.359352
Show Author Affiliations
Chiu Chau, BioArray Solutions, LLC (United States)
Sukanta Banerjee, BioArray Solutions, LLC (United States)
Michael Seul, BioArray Solutions, LLC (United States)

Published in SPIE Proceedings Vol. 3877:
Microfluidic Devices and Systems II
Chong Hyuk Ahn; A. Bruno Frazier, Editor(s)

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