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Proceedings Paper

Real-time optical imaging and spectroscopy of brain ischemia and hemorrhage
Author(s): Miljan R. Stankovic M.D.; Dennis M. Hueber; Dev Maulik; Phillip G. Stubblefield; Warren Rosenfeld; Enrico Gratton; Maria-Angela Franceschini; Sergio Fantini
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Paper Abstract

Perinatal brain injury, a major cause of neurological morbidity in infants, might be prevented or ameliorated if the preceding cerebrovascular disturbances known to cause brain ischemia and hemorrhage could be detected and monitored. We used an ISS tissue oximeter (model 96208, 110 MHz modulated light at two NIR wavelengths) to detect and monitor the development of experimental brain ischemia and hemorrhage by frequency domain optical spectroscopy (8-source/1-detector probe) and CW imaging (16-source/2-detector probe) in nineteen instrumented and ventilated newborn piglets. Our study demonstrates: 1) the sensitivity of the ISS system to detect <0.04 mL of blood at a depth of 1-2 cm; 2) the specificity to distinguish subcortical, subarachnoid, and intraventricular hemorrhage; 3) the possibility of using the optically detected arterial pulse signal to differentiate injured from functional brain regions. In the case of subcortical hemorrhage, we observed that the measured cerebral pa increased linearly with the sectional area of the hematoma rather than with the volume of injected blood. A 1-min movie clip demonstrates the ability of the ISS system to perform the very fast (0.19 s per image) imaging of the developing brain ischemia and hemorrhage.

Paper Details

Date Published: 15 July 1999
PDF: 9 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356808
Show Author Affiliations
Miljan R. Stankovic M.D., SUNY/Stony Brook and Boston Univ. (United States)
Dennis M. Hueber, ISS, Inc. (United States)
Dev Maulik, SUNY/Stony Brook (United States)
Phillip G. Stubblefield, Boston Univ. (United States)
Warren Rosenfeld, SUNY/Stony Brook (United States)
Enrico Gratton, Univ. of Illinois/Urbana-Champaign (United States)
Maria-Angela Franceschini, Univ. of Illinois/Urbana-Champaign (United States)
Sergio Fantini, Univ. of Illinois/Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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