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Proceedings Paper

Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion
Author(s): Lelia Adelina Paunescu; Claudia Casavola; Maria-Angela Franceschini; Sergio Fantini; Lew Winter; Jin Kim; Debra Wood; Enrico Gratton
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Paper Abstract

We present non-invasive measurements of the calf muscle blood flow (BF) and oxygen consumption (OC) by near-infrared spectroscopy. We used a frequency domain tissue oximeter (modulation frequency: 110 MHz, wavelengths: 758 and 830 nm) to measure in real time (acquisition time: 0.64 s) the hemoglobin concentration and saturation. After 1-min of baseline acquisition, we achieved venous occlusion by inflating a pneumatic cuff on the subjectÕs thigh to a pressure of 60 mmHg. The cuff was released after 1 min. The baseline/inflation/release procedure was repeated 3 times to verify reproducibility. We calculated the BF and OC from the initial rate of increase of the total hemoglobin and deoxy-hemoglobin concentration immediately after the onset of venous occlusion. We examined 8 healthy subjects and 18 patients affected by peripheral vascular disease (PVD) in 1 or 2 legs to investigate whether muscle BF and OC at rest can be useful indicators of vascular insufficiency. In healthy legs, we obtained average values of BF=0.73 ml/(100ml)/min and OC=0.10 ml/(100g)/min. The corresponding average values found in legs affected by PVD are BF=1.39 ml/(100ml)/min and OC=0.16 ml/(100g)/min. The ranges of values of BF and OC measured in the healthy legs broadly overlap with the corresponding ranges measured in the PVD legs.

Paper Details

Date Published: 15 July 1999
PDF: 7 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356790
Show Author Affiliations
Lelia Adelina Paunescu, Univ. of Illinois/Urbana-Champaign (United States)
Claudia Casavola, Univ. of Illinois/Urbana-Champaign and Univ. degli Studi di Bari (Italy)
Maria-Angela Franceschini, Univ. of Illinois/Urbana-Champaign (United States)
Sergio Fantini, Univ. of Illinois/Urbana-Champaign (United States)
Lew Winter, Danville Veterans Affairs Medical Ctr. (United States)
Jin Kim, Danville Veterans Affairs Medical Ctr. (United States)
Debra Wood, Danville Veterans Affairs Medical Ctr. (United States)
Enrico Gratton, Univ. of Illinois/Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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