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Proceedings Paper

Use of entangled-photon imaging in optical biopsy: a feasibility study
Author(s): Ervin Goldfain
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Paper Abstract

We examine a novel diagnostic method suitable for optical biopsy, i.e., the noninvasive in vivo detection of malignant lesions in human tissue. Entangled-photon imaging is an emerging technology based upon the use of non-classical sources of light such as optical parametric oscillators (OPO). These sources generate above-threshold signal and idler beams that have intensity fluctuations highly correlated in space and time (twin beams). It has been shown that low-intensity OPO's make possible high sensitivity absorption measurements of weak targets, below the shot- noise limit. The direct use of this technology for optical biopsy is severely restricted by the large amount of scattering noise associated with light-tissue interaction. We report what is, to our knowledge, the first feasibility study on a differential wavelength, OPO-based setup targeted for mammography. Constraints related to the entanglement time, OPO selection and background suppression are analyzed. The paper concludes with a review of future developments and challenges.

Paper Details

Date Published: 19 July 1999
PDF: 2 pages
Proc. SPIE 3749, 18th Congress of the International Commission for Optics, (19 July 1999); doi: 10.1117/12.354947
Show Author Affiliations
Ervin Goldfain, Welch Allyn, Inc. (United States)

Published in SPIE Proceedings Vol. 3749:
18th Congress of the International Commission for Optics
Alexander J. Glass; Joseph W. Goodman; Milton Chang; Arthur H. Guenther; Toshimitsu Asakura, Editor(s)

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