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Proceedings Paper

Noninvasive NIR measurement of tissue pH to assess hemorrhagic shock in swine
Author(s): Babs R. Soller; Songbiao Zhang; Ronald H. Micheels; Juan Carlos Puyana
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Paper Abstract

Body-worn noninvasive physilogical sensors are needed to continuously monitor soldiers for hemorrhage and to provide real-time information for minimally skilled medics to treat the injured. In the hospital intramucosal pHi of the gut is used to monitor shock and its treatment. We hypothesize that abdominal wall muscle (AWM) pH can be measured noninvasively using near infrared (NIR) spectroscopy and partial least squares analysis (PLS) and will correlate with pHi. METHODS: AWM pH was measured with microelectrodes and gastric pHi was measured with a tonometric catheter simultaneously while NIR spectra were collected using prototype LED spectrometers placed on the pig's flanks. Animals were subject to hemorrhagic shock at 45 mm Hg for 45 minutes, then resuscitated with blood and lactated ringers. Relationships between electrode pH, pHi and NIR spectra were developed using PLS with cross validation. RESULTS: NIR spectral changes noninvasively acquired through the skin were shown to be from the muscle, not from changes in skin blood flow. Trending ability (R2) model accuracy (RMSD), and relative error were calculated for individual pigs. Using electrode pH as the reference, average R2 was 0.88 with a predicted accuracy of 0.17 pH units, a 9.3% relative error. Slightly degraded results were observed when pHi was used as a reference. CONCLUSIONS: NIR measurement of tissue pH can be used to noninvasively monitor for shock and guide its treatment in a swine model. These measurements correlate with gastric pHi, a clinically accepted measure of shock, providing an approach to develop similar methodology for humans.

Paper Details

Date Published: 13 July 1999
PDF: 8 pages
Proc. SPIE 3712, Battlefield Biomedical Technologies, (13 July 1999); doi: 10.1117/12.353018
Show Author Affiliations
Babs R. Soller, Univ. of Massachusetts Medical School (United States)
Songbiao Zhang, Univ. of Massachusetts Medical School (United States)
Ronald H. Micheels, Polestar Technologies, Inc. (United States)
Juan Carlos Puyana, Brigham and Women's Hospital (United States)

Published in SPIE Proceedings Vol. 3712:
Battlefield Biomedical Technologies
Homer H. Pien, Editor(s)

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