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Proceedings Paper

D-light for laparoscopic fluorescence diagnosis
Author(s): Johannes Gahlen; Hans-Heinrich Laubach; Josef Stern; Jochen Pressmar; Mathias Pietschmann; Christian Herfarth
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Paper Abstract

To evaluate the role of ALA induced fluorescence diagnosis in laparoscopic surgery, we induced peritoneal carcinosis in rats by multilocular intraabdominal tumorcell implantation (CC531). The animals were photosensitized by intraabdominal ALA lavage. Laparoscopy was performed with both, conventional white and then blue light (D-Light, KARL STORZ Germany) excitation. Laparoscopy with conventional white light showed peritoneal carcinoma foci from 0.1 to 2 cm in diameter. All macroscopically visible tumors (n equals 142) were fluorescence positive after laparoscopic blue light excitation. In addition, 30 laparoscopic not visible (white light) tumors showed fluorescence and were histologically confirmed as colon carcinoma metastases. We conclude that only ALA induced laparoscopic fluorescence detection after blue light excitation is the adequate method to detect the entire extent of the intraabdominal tumor spread. Fluorescence laparoscopy is essential for laparoscopic staging of colorectal cancer because of a higher rate of cancer foci detection.

Paper Details

Date Published: 6 July 1999
PDF: 6 pages
Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); doi: 10.1117/12.351509
Show Author Affiliations
Johannes Gahlen, Chirurgische Universitaetsklinik Heidelberg (Germany)
Hans-Heinrich Laubach, Chirurgische Universitaetsklinik Heidelberg (Germany)
Josef Stern, Chirurgische Universitaetsklinik Heidelberg (Germany)
Jochen Pressmar, Chirurgische Universitaetsklinik Heidelberg (Germany)
Mathias Pietschmann, Chirurgische Universitaetsklinik Heidelberg (Germany)
Christian Herfarth, Chirurgische Universitaetsklinik Heidelberg (Germany)

Published in SPIE Proceedings Vol. 3592:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII
Thomas J. Dougherty, Editor(s)

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