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Proceedings Paper

Single-virus analysis by correlated optical spectroscopy and atomic force microscopy
Author(s): Warren C. W. Chan; Shuming Nie
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Paper Abstract

Single adeno- and tobacco mosaic viruses have been studied by correlated fluorescence spectroscopy and tapping-mode atomic force microscopy. The size and shape of spatially isolated, fluorescently tagged viruses are measured on the nanometer scale, and the fluorescent labels in each virus are determined by wavelength-resolved spectroscopy. This work extends ultrasensitive measurement to the single-virus level and is expected to have applications in studying gene therapy vectors and virus-cell interactions.

Paper Details

Date Published: 17 June 1999
PDF: 8 pages
Proc. SPIE 3607, Scanning and Force Microscopies for Biomedical Applications, (17 June 1999); doi: 10.1117/12.350617
Show Author Affiliations
Warren C. W. Chan, Indiana Univ. (United States)
Shuming Nie, Indiana Univ. (United States)

Published in SPIE Proceedings Vol. 3607:
Scanning and Force Microscopies for Biomedical Applications
Eiichi Tamiya; Shuming Nie, Editor(s)

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