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Proceedings Paper

Acute optic nerve sheath fenestration with the free-electron laser
Author(s): Jin-Hui Shen; Vivien A. Casagrande; Karen Margaret Joos M.D.; Debra J. Shetlar; Richard D. Robinson; William S. Head; Julia A. Mavity-Hudson; Amy H. Nunnally
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Paper Abstract

Purpose: To determine if the free electron laser (FEL) energy can be delivered to a small space to perform optic nerve sheath fenestration with minimal acute nerve damage. Methods: A 530 mm hollow waveguide probe was designed. Optic nerve sheath fenestration (1.0 mm diameter) was performed in 8 rabbits using either the FEL (4 eyes, 6.45mm, 10 Hz, 2 mJ) or a knife (4 eyes). Within 2 hours following surgery, the animals were perfused with aldehyde fixative. The integrity of the optic nerve and glial response at the site of fenestration were evaluated on tissue selections with H&E, and antibodies to S100β or GFAP. Results: Surgery using the FEL probe was found to be technically superior to the knife. The glial reaction was limited to a zone adjacent to the fenestration and was similar in both the FEL and knife incisions. Conclusions: The FEL appears capable of efficiently performing an optic nerve sheath fenestration in a small space with minimal acute damage. Both the FEL and knife incisions result in a rapid glial response at the site of fenestration even when optic nerve integrity is not compromised.

Paper Details

Date Published: 18 June 1999
PDF: 6 pages
Proc. SPIE 3591, Ophthalmic Technologies IX, (18 June 1999); doi: 10.1117/12.350585
Show Author Affiliations
Jin-Hui Shen, Vanderbilt Univ. (United States)
Vivien A. Casagrande, Vanderbilt Univ. (United States)
Karen Margaret Joos M.D., Vanderbilt Univ. (United States)
Debra J. Shetlar, Vanderbilt Univ. (United States)
Richard D. Robinson, Vanderbilt Univ. (United States)
William S. Head, Vanderbilt Univ. (United States)
Julia A. Mavity-Hudson, Vanderbilt Univ. (United States)
Amy H. Nunnally, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 3591:
Ophthalmic Technologies IX
Bruce E. Stuck; Pascal O. Rol; Michael Belkin M.D.; Karen Margaret Joos M.D.; Fabrice Manns; Bruce E. Stuck; Michael Belkin M.D., Editor(s)

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