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Proceedings Paper

Ultrasound interstitial thermal therapy (USITT) in the prostate
Author(s): William H. Nau; Chris J. Diederich; Dana L. Deardorff
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Paper Abstract

This research represents an experimental investigation of the use of interstitial catheter-cooled ultrasound applicators in various treatment strategies for the management of localized prostate cancer and benign prostatic hyperplasia. The anticipated clinical approaches under consideration were: (1) Ultrasound Interstitial Thermal therapy (USITT) alone for treatment of the whole gland, (2) high dose rate (HDR) brachytherapy with USITT to treat local recurrences or extracapsular extensions of the disease, and (3) sequence HDR brachytherapy and hyperthermia. Directional multielement catheter-cooled ultrasound applicators were fabricated using cylindrical piezoceramic transducers which can be inserted into 13 or 14 gage catheters. The applicators were characterized through measurements of acoustic power output, and beam profile distributions in degassed water. Thermal lesion formation studies were performed in an in vitro setup using fresh beef muscle. Various implant strategies were evaluated for the ability to control the temperature distribution within a pre-determined volume of tissue. Lesions extending more than 15 mm from the applicator surface were generated within 5 minutes of heating. Preliminary results from this study demonstrate the versatility of catheter-cooled interstitial ultrasound applicators, and their potential to provide controlled thermal therapy in the prostate.

Paper Details

Date Published: 19 May 1999
PDF: 9 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348745
Show Author Affiliations
William H. Nau, Univ. of California/San Francisco (United States)
Chris J. Diederich, Univ. of California/San Francisco (United States)
Dana L. Deardorff, Univ. of California/San Francisco (United States)

Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong M.D., Editor(s)

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