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Proceedings Paper

Laser optoacoustic technique for real-time measurement of thermal damage in tissues
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Paper Abstract

Optoacoustic monitoring of thermally-induced damage in tissues in real time is proposed as a mean for controlling the extent of tissue coagulation in human organs, such as liver, prostate, myocardium, breast, and brain. This technique can potentially provide fast and accurate feedback information during tumor thermal coagulation by interstitial delivery of laser, ultrasonic, radiofrequency, and microwave radiation or conductive and convective heating. Amplitude and temporal characteristics of optoacoustic signals are dependent on optical and thermophysical properties of tissues. Changes in tissue optical properties during coagulation can be detected by measuring and analyzing the amplitude and temporal characteristics of the optoacoustic signals. We performed studies on optoacoustic monitoring of coagulation by CW Nd:YAG laser interstitial irradiation and conductive heating. Q-switched Nd:YAG laser pulses were used as a probing radiation to obtain optoacoustic pressure profiles and images. Our preliminary studies suggest that the laser optoacoustic technique is capable of detecting thermally-induced changes in optical properties of liver, myocardium, and prostate. The major merits of the laser optoacoustic monitoring of tissue coagulation include high contrast provided by changes in tissue optical properties, capability to perform real-time measurements, and high spatial resolution.

Paper Details

Date Published: 19 May 1999
PDF: 12 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348727
Show Author Affiliations
Rinat O. Esenaliev, Univ. of Texas Medical Branch (United States)
Irina V. Larina, Univ. of Texas Medical Branch (United States)
Kirill V. Larin, Univ. of Texas Medical Branch (United States)
Massoud Motamedi, Univ. of Texas Medical Branch (United States)
Alexander A. Karabutov, Univ. of Texas Medical Branch (United States)
Alexander A. Oraevsky, Univ. of Texas Medical Branch (United States)

Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong M.D., Editor(s)

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