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Proceedings Paper

Bayesian inference for neural electromagnetic source localization: analysis of MEG visual evoked activity
Author(s): David M. Schmidt; John S. George; C. C. Wood
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Paper Abstract

We have developed a Bayesian approach to the analysis of neural electromagnetic (MEG/EEG) data that can incorporate or fuse information from other imaging modalities and addresses the ill-posed inverse problem by sampling the many different solutions which could have produced the given data. From these samples one can draw probabilistic inferences about regions of activation. Our source model assumes a variable number of variable size cortical regions of stimulus-correlated activity. An active region consists of locations on the cortical surface, within a sphere centered on some location in cortex. The number and radii of active regions can vary to defined maximum values. The goal of the analysis is to determine the posterior probability distribution for the set of parameters that govern the number, location, and extent of active regions. Markov Chain Monte Carlo is used to generate a large sample of sets of parameters distributed according to the posterior distribution. This sample is representative of the many different source distributions that could account for given data, and allows identification of probable (i.e. consistent) features across solutions. Examples of the use of this analysis technique with both simulated and empirical MEG data are presented.

Paper Details

Date Published: 21 May 1999
PDF: 12 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348596
Show Author Affiliations
David M. Schmidt, Los Alamos National Lab. (United States)
John S. George, Los Alamos National Lab. (United States)
C. C. Wood, Los Alamos National Lab. (United States)

Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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