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Proceedings Paper

Time-dependent speckle contrast measurements for blood microcirculation monitoring
Author(s): Dmitry A. Zimnyakov; Alexey B. Mishin; Andrey A. Bednov; Cecil Cheung; Valery V. Tuchin; Arjun G. Yodh
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Paper Abstract

Features of the speckle patterns formation due to the laser light propagation in multiple scattering systems which influence on the accuracy of measurement of the scattering system dynamic parameters by means of statistical analysis of the time-averaged spatial speckle intensity fluctuations have been studied experimentally. Two different experimental techniques have been used: photon correlation spectroscopy and contrast analysis for time-averaged speckle patterns similar to LASCA method. Results of in-vivo experiments as well as experiments with model scattering media (water solution of Intralipid) are presented. Recommendations about the choose of appropriate data processing algorithms as well as about calibration technique for time-averaged speckle technique are discussed.

Paper Details

Date Published: 17 May 1999
PDF: 10 pages
Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); doi: 10.1117/12.348369
Show Author Affiliations
Dmitry A. Zimnyakov, Saratov State Univ. (Russia)
Alexey B. Mishin, Saratov State Technical Univ. (Russia)
Andrey A. Bednov, Saratov State Univ. (United States)
Cecil Cheung, Univ. of Pennsylvania (United States)
Valery V. Tuchin, Saratov State Univ. (Russia)
Arjun G. Yodh, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 3599:
Optical Diagnostics of Biological Fluids IV
Alexander V. Priezzhev; Toshimitsu Asakura, Editor(s)

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