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Proceedings Paper

Biological assays in microfabricated structures
Author(s): Daniel M. Fishman; Thomas L. Fare; Qianping Dong; Z. Hugh Fan; Timothy J. Davis; Rajan Kumar
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Paper Abstract

Microfluidic control in microfabricated glass channels enables miniaturized, fast, and multianalyte assays. We are applying this technology in several areas, including real- time environmental monitoring for airborne biological agents. Two complementary approaches are being used in parallel. the first is assaying for the presence of nucleotide sequences that are markers for specific hazardous, engineered bacteria. The second is an assay that monitors the functionality of an in vitro biochemical pathway, in which the pathway that is chosen is sensitive to the presence of the class of toxins to be detected. The first approach is discussed here. The detected signal from the nucleic-acid-based assay is from fluorescently labeled probes that hybridize to bead-bound amplified DNA sequences. Detection approaches and their benefits will be discussed.

Paper Details

Date Published: 21 April 1999
PDF: 6 pages
Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II, (21 April 1999); doi: 10.1117/12.346741
Show Author Affiliations
Daniel M. Fishman, Sarnoff Corp. (United States)
Thomas L. Fare, Sarnoff Corp. (United States)
Qianping Dong, Sarnoff Corp. (United States)
Z. Hugh Fan, Sarnoff Corp. (United States)
Timothy J. Davis, Sarnoff Corp. (United States)
Rajan Kumar, Sarnoff Corp. (United States)

Published in SPIE Proceedings Vol. 3603:
Systems and Technologies for Clinical Diagnostics and Drug Discovery II
Gerald E. Cohn; John C. Owicki, Editor(s)

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