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Proceedings Paper

Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids
Author(s): D. Patrick O'Neal; Massoud Motamedi; Jefferson Chen M.D.; Gerard L. Cote
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Paper Abstract

Traditionally methods for the detection of excitatory amino acids, which have been linked to secondary injury following head trauma, can be excessively time consuming clinically. A near real-time measurement system could provide clinical information in anticipation of pharmaceutical intervention for head injured patients. Our studies have shown that surface-enhanced Raman spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro excitatory amino acids using short scan times. Employing a damage model for ischemia, preliminary ex vivo rat extracellular grain fluid analysis shows an intriguing correlation between SERS spectral features and expected Glutamate concentration fluctuations following head injuries.

Paper Details

Date Published: 9 April 1999
PDF: 6 pages
Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); doi: 10.1117/12.345404
Show Author Affiliations
D. Patrick O'Neal, Texas A&M Univ. (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)
Jefferson Chen M.D., Univ. of Texas Medical Branch at Galveston (United States)
Gerard L. Cote, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 3608:
Biomedical Applications of Raman Spectroscopy
Michael D. Morris, Editor(s)

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