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Proceedings Paper

Tissue diagnostics using fiber optic FTIR spectroscopy
Author(s): Uwe Bindig; Wolfgang Waesche; K. Liebold; Harald Winter; Ulrich M. Gross; P. Frege; G. Mueller
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Paper Abstract

The infrared spectrum of biological tissue is due to the 'microheterogenous' composition as a whole and is based on complex vibrational modes. In detail, the spectrum represents the biochemical status resulting from a combination of the structural framework of tissues together with the biological active compounds of metabolism. According to the literature, the main IR-spectroscopic differences are to be expected by the characteristic spectral pattern which is located at the 'fingerprint' region (1500 - 1000 cm-1). In order to design and develop an endoscopic system for the in vivo identification of healthy and malignant tissue FTIR- measurements were carried out using a fiberoptic device. The source of IR-radiation can be either the FTIR-spectrometer or tunable IR-diode lasers. Fiberoptic IR-spectra obtained using the attenuated total reflectance (ATR) and reflection mode were compared to spectra resulting from the FTIR- microspectroscopic measurements.

Paper Details

Date Published: 19 January 1999
PDF: 8 pages
Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); doi: 10.1117/12.336815
Show Author Affiliations
Uwe Bindig, Laser- und Medizin-Technologie gGmbH (Germany)
Wolfgang Waesche, Univ. Hospital Charite/Humboldt Univ. zu Berlin (Germany)
K. Liebold, Laser- und Medizin-Technologie gGmbH (Germany)
Harald Winter, Laser- und Medizin-Technologie gGmbH (Germany)
Ulrich M. Gross, Univ. Hospital Benjamin Franklin/Freie Univ. Berlin (Germany)
P. Frege, Univ. Hospital Benjamin Franklin/Freie Univ. Berlin (Germany)
G. Mueller, Laser- und Medizin-Technologie gGmbH and Freie Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 3568:
Optical Biopsies and Microscopic Techniques III
Irving J. Bigio; Herbert Schneckenburger; Jan Slavik; Katarina Svanberg M.D.; Pierre M. Viallet, Editor(s)

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