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Proceedings Paper

In-vivo characterization of tissue efflux rates of cyanine dyes by near-infrared spectroscopy
Author(s): Kai Licha; Vasilis Ntziachristos; Bjoern Riefke; Andreas Becker; Britton Chance; Wolfhard Semmler
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Paper Abstract

Optical mammography is a new imaging modality currently under development. A contrast agent capable of adding malignancy differentiation signatures is expected to enhance the sensitivity and specificity characteristics of the technique. We report the in vivo characterization of hydrophilic analogs of indocyanine green (ICG) that lead to enhanced tumor absorbance compared to surrounding tissue. The tumor efflux of these dyes was quantitatively studied in tumor-bearing rats by frequency-modulated near-infrared spectroscopy. We demonstrate that the half-lives of hydrophilic cyanine dyes in tumor tissue are considerably enhanced compared to ICG, thus providing a prolonged time window for diagnosis. Moreover, absorption differences between the tumor and normal tissue were observed for 3 hours after injection of the hydrophilic glucamine derivative NIR96010. In conclusion, pharmacokinetic properties as present with NIR96010 may facilitate contrast- agent-aided optical mammography.

Paper Details

Date Published: 30 December 1998
PDF: 8 pages
Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); doi: 10.1117/12.334359
Show Author Affiliations
Kai Licha, Institut fuer Diagnostikforschung/Freie Univ. Berlin (Germany)
Vasilis Ntziachristos, Univ. of Pennsylvania School of Medicine (United States)
Bjoern Riefke, Institut fuer Diagnostikforschung/Freie Univ. Berlin (Germany)
Andreas Becker, Institut fuer Diagnostikforschung/Freie Univ. Berlin (Germany)
Britton Chance, Univ. of Pennsylvania School of Medicine (United States)
Wolfhard Semmler, Institut fuer Diagnostikforschung/Freie Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 3566:
Photon Propagation in Tissues IV
David A. Benaron M.D.; Britton Chance; Marco Ferrari; Matthias Kohl-Bareis, Editor(s)

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