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Proceedings Paper

Measurement of in-vivo hemoglobin concentration using diffuse reflectance
Author(s): Ashley D. Hunter; John A. Crowe; John G. Walker
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Paper Abstract

A means of determining the concentration of hemoglobin in- vivo using diffuse reflectance is proposed which could be applied to the quantification of laser Doppler flowmetry data. Monte Carlo simulations were used to generate intensity vs. source-detector separation plots for optical fibers of 200 micrometers diameter, with separations up to 6 mm on the skin surface. The plots were then fitted to the equation; I(x) equals a0.exp(-a1x + a2x2) and a polynomial function derived for a1 that is dependent upon the reduced scattering, microsecond(s) ', and absorption, (mu) a, coefficients. Experimentally two wavelengths with a known difference in the absorption coefficient of hemoglobin, but sharing the same microsecond(s) ', are used to solve simultaneously the derived function for (mu) a, and give the hemoglobin concentration.

Paper Details

Date Published: 30 December 1998
PDF: 9 pages
Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); doi: 10.1117/12.334355
Show Author Affiliations
Ashley D. Hunter, Univ. of Nottingham (United Kingdom)
John A. Crowe, Univ. of Nottingham (United Kingdom)
John G. Walker, Univ. of Nottingham (United Kingdom)

Published in SPIE Proceedings Vol. 3566:
Photon Propagation in Tissues IV
David A. Benaron M.D.; Britton Chance; Marco Ferrari; Matthias Kohl-Bareis, Editor(s)

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