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Proceedings Paper

Optical properties of normal and carcinomatous human lung tissues at 406.7 ~ 415.4 nm of a violet Kr+ laser
Author(s): Shusen Xie; Wei Zheng; Qirong Lin; Buhong Li; Zhiwei Huang; Teck-Chee Chia
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Paper Abstract

To understand better the optical characteristics of normal and carcinomatous lung tissues in the clinical photodynamic diagnosis and light dosimetry, we measured the effective attenuation coefficient (mu) eff, absorption coefficient (mu) s and reduced scattering coefficient at 406.7-415.4 nm. We performed the measurements by using 'Depthometer with Isotropic Fiber-optic Probe' developed by ourselves accurately to measure the fluence rate distributions in the fresh samples during irradiation with a collimated broad beam of a violet Kr+ laser. The total diffuse reflectance Rd was also measured by using a flat-cut optical fiber to guide the light into a detector. Some conclusions of adding-doubling method as well as diffusion theory were utilized to derive the optical properties of the measured tissue. The optical penetration depths of normal and adeno-squamous carcinoma human lung tissues are 0.08 mm and 0.32 mm respectively. We believe that it is the first set of data of 6 at 4.6.7-415.4 nm for fresh human lung tissue.

Paper Details

Date Published: 2 November 1998
PDF: 9 pages
Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); doi: 10.1117/12.330161
Show Author Affiliations
Shusen Xie, Fujian Normal Univ. (China)
Wei Zheng, Fujian Normal Univ. (China)
Qirong Lin, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Zhiwei Huang, Nanyang Technological Univ. (Canada)
Teck-Chee Chia, Nanyang Technological Univ. (Singapore)

Published in SPIE Proceedings Vol. 3344:
1997 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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