To understand better the optical characteristics of normal and carcinomatous lung tissues in the clinical photodynamic diagnosis and light dosimetry, we measured the effective attenuation coefficient (mu) _eff, absorption coefficient (mu) _s and reduced scattering coefficient at 406.7-415.4 nm. We performed the measurements by using 'Depthometer with Isotropic Fiber-optic Probe' developed by ourselves accurately to measure the fluence rate distributions in the fresh samples during irradiation with a collimated broad beam of a violet Kr⁺ laser. The total diffuse reflectance R_d was also measured by using a flat-cut optical fiber to guide the light into a detector. Some conclusions of adding-doubling method as well as diffusion theory were utilized to derive the optical properties of the measured tissue. The optical penetration depths of normal and adeno-squamous carcinoma human lung tissues are 0.08 mm and 0.32 mm respectively. We believe that it is the first set of data of 6 at 4.6.7-415.4 nm for fresh human lung tissue.

Date Published: 2 November 1998
PDF: 9 pages
Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); doi: 10.1117/12.330161

Published in SPIE Proceedings Vol. 3344:
1997 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)