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Proceedings Paper

Initiation of apoptosis by photosensitization with hypocrellin A and the repression of Vitamin E
Author(s): En-Hua Cao; Jian Zhang; Jingfu Li
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Paper Abstract

PDT-induced HeLa cells apoptosis was evidenced by morphological changes, DNA fragmentation and decrease of mitochondria dehydrogenase activity. Apoptosis was associated with the formation of IP3 of photosensitized cells and rapid release of Ca2+ from intracellular pools. Vitamin E, which was added before irradiation, could significantly protect cells against cell death, indicating that reactive oxygen species (ROS) play an important role in apoptotic cell death.

Paper Details

Date Published: 7 August 1998
PDF: 8 pages
Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); doi: 10.1117/12.317884
Show Author Affiliations
En-Hua Cao, Institute of Biophysics (China)
Jian Zhang, Institute of Biophysics (China)
Jingfu Li, Institute of Biophysics (China)

Published in SPIE Proceedings Vol. 3548:
Biomedical Optics and Lasers: Diagnostics and Treatment
Junheng Li M.D.; James A. Harrington, Editor(s)

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