Share Email Print

Proceedings Paper

Low-coherence tomography technique in biological tissues
Author(s): Ge Kou; Wanrong Gao; ChunKan Tao; Luguo Hao
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Low coherence optical tomography (OCT) is a novel technique with high resolution for rapid, noninvasive imaging in living biological tissues. With this technique, a thin 'optical section' within a thick biological specimen can be obtained. Using a combination of the principles of low-coherence interferometry and confocal microscopy, OCT can provide micron-scale tomographic imaging of internal tissue microstructures. In OCT, enhanced optical sectioning performance in biological tissues (highly scattering media) is achieved through high detection sensitivity and high contrast rejection of out-of-focus light. In this paper, basic principle and recent advances in optical coherence tomography are described. The emphasis is to analyze some key problems in OCT setup. Light attenuation and scanning system are studied in detail. A theoretical model for low-coherence optical tomography in highly scattering media (biological tissues) is given. The authors will show that OCT images may be significantly affected by multiple scattering associated with the refractive index inhomogeneities found in scattering media such as biological tissues. At last, a conclusion suggests that OCT is a very promising technique for clinical application because of its simple theory and low cost.

Paper Details

Date Published: 7 August 1998
PDF: 5 pages
Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); doi: 10.1117/12.317852
Show Author Affiliations
Ge Kou, Nanjing Univ. of Science and Technology (China)
Wanrong Gao, Nanjing Univ. of Science and Technology (China)
ChunKan Tao, Nanjing Univ. of Science and Technology (China)
Luguo Hao, Nanjing Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 3548:
Biomedical Optics and Lasers: Diagnostics and Treatment
Junheng Li M.D.; James A. Harrington, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?