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Proceedings Paper

Cross method for analysis of the erythrocyte sedimentation rate and aggregation coefficient in medical diagnostics
Author(s): Irene V. Yamaikina; Dmitryi A. Furmanchuk
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Paper Abstract

Method of erythrocyte sedimentation rate (ESR) measurement is non-specific one. The ESR are tightly correlated to increase or decrease of aggregation coefficient (N). The variations of N could happen due to two main reasons: either changes in concentration of plasma proteins (first of all of fibrinogen) or changes of erythrocyte membrane characteristics (surface charge, transmembrane potential). The cross-method of ESR analysis has been proposed, using blood samples from patient and healthy donor of the same ABO blood groups and Rh-factors. The hematocrit (Ho)-ESR dependencies were measured in four variants: (1) patient's erythrocytes in patient's plasma; (2) patient's erythrocytes in donor's plasma; (3) donor's erythrocytes in donor's plasma; (4) donor's erythrocytes in patient's plasma. On presenting the ESR data for more than 100 patients with different bone marrow disorders after chemotherapy in the coordinates Ho-ESR three conventional zones could be marked out: high-ESR zone, medium zone and zone of low level of Ho. Proposed cross-method allows to estimate which of the two aforementioned reasons results in ESR variation. Some patients revealed not only changed fibrinogen level but additional changes in membrane affinity to fibrinogen. The modificated ESR cross-method opens us some new capacities in medical diagnostics.

Paper Details

Date Published: 19 June 1998
PDF: 5 pages
Proc. SPIE 3252, Optical Diagnostics of Biological Fluids III, (19 June 1998); doi: 10.1117/12.311890
Show Author Affiliations
Irene V. Yamaikina, A.V. Luikov Heat and Mass Transfer Institute (Belarus)
Dmitryi A. Furmanchuk, Republican Pediatric Ctr. of Hemato-oncology (Belarus)

Published in SPIE Proceedings Vol. 3252:
Optical Diagnostics of Biological Fluids III
Alexander V. Priezzhev; Toshimitsu Asakura; J. David Briers, Editor(s)

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