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Proceedings Paper

Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment
Author(s): Robert E. Nordquist; John A. Nordquist; James C. Agee; Chad M. Blomquist; Wei R. Chen
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Paper Abstract

Laser immunotherapy, using a combination of 805 nm diode laser, photosensitizer indocyanine green and immunoadjuvant glycated chitosan, has shown an induced anti-tumor immune response in treatment of metastatic rat tumors. In additional to an apparent systemic, long-term humoral immunological reaction, there could also be laser induced local cellular immune responses. A morphological study was performed to study the immune cells and their infiltration to tumor tissue after this laser immunotherapy treatment. Tumor-bearing rats were terminated at designated times after the treatment; both the tumor and the surrounding normal tissue were collected. The tissue samples were observed under electron microscope. The number and types of infiltrating cells at the tumor site were studied after treatment to determine the contribution of these cells in the elimination of tumors. The tumor cell structural changes resulted from laser-tissue photothermal interaction was investigated. The morphology of tumor development and activities of immune cells including both lymphocytes and plasma cells could shed light on the mode of action of laser treatment of tumors.

Paper Details

Date Published: 13 May 1998
PDF: 6 pages
Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308195
Show Author Affiliations
Robert E. Nordquist, Wound Healing of Oklahoma, Inc. (United States)
John A. Nordquist, Wound Healing of Oklahoma, Inc. (United States)
James C. Agee, Oklahoma School of Science and Mathematics (United States)
Chad M. Blomquist, Oklahoma School of Science and Mathematics (United States)
Wei R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma (United States)

Published in SPIE Proceedings Vol. 3254:
Laser-Tissue Interaction IX
Steven L. Jacques; Jeff Lotz, Editor(s)

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