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Proceedings Paper

Effects of stress waves on cells
Author(s): Heather L. Campbell; Steven R. Visuri; Luiz Barroca Da Silva
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Paper Abstract

Laser induced stress waves are being used in a variety of medical applications, including drug delivery and targeted tissue disruption. Stress waves can also be an undesirable side effect in laser procedures such as ophthalmology and angioplasty. Thus, a study of the effects of stress waves on a cellular level is useful. Thermoplastic stress waves were produced using a Q-switched frequency-doubled Nd:YAG laser (lambda equals 532 nm) with a pulse duration of 4 ns. The laser radiation was delivered to an absorbing media. A thermoplastic stress wave was produced in the absorbing media and propagated into plated cells. The energy per pulse delivered to a sample and the spot size were varied. Stress waves were quantified. We assayed for cell viability and damage using two methods. The threshold laser parameters for cell damage were defined for three cell lines.

Paper Details

Date Published: 13 May 1998
PDF: 5 pages
Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308152
Show Author Affiliations
Heather L. Campbell, Lawrence Livermore National Lab. (United States)
Steven R. Visuri, Lawrence Livermore National Lab. (United States)
Luiz Barroca Da Silva, Lawrence Livermore National Lab. (United States)

Published in SPIE Proceedings Vol. 3254:
Laser-Tissue Interaction IX
Steven L. Jacques; Jeff Lotz, Editor(s)

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