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Proceedings Paper

Spectral-selective fluorescence imaging for diagnostics of surface cancer
Author(s): Alexander V. Vinogradov; Alexey I. Trushin; Pavel G. Leonov; Michael L. Stahanov
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Paper Abstract

We report on porphyrin autofluorescence imaging diagnostic of surface cancer. Digital computer fluorescent methods get real time, non-invasive, in vivo cancer diagnostic. Output information has clear picture form. Results may be placed in imaging data bases and sent via computer networks. We received our laboratory results without exogenous porphyrins or pharmaceutical stimulation of endogenous porphyrin production. The results were confirmed by histological tests. Autofluorescence was exited via He-Ne laser. Extra sensitive digital TV system was used for image capturing. Image was grabbed in the narrow spectral fluorescence band about 680 nm. The fluorescent image delivered quantity information on the porphyrin spatial distribution. Bright spots on the image were cancer suspected places. We combined usual color image with the fluorescent image and marked suspected places. Then these places were tested by standard diagnostic methods. Combination of image fluorescent and standard methods allowed us to find out invisible or very small cancer lesions. In our report we discuss the relation between traditional laser induced fluorescent spectroscopy diagnostic and fluorescent imaging. In our opinion the method is especially efficient at early disease stages, when lesion is very compact and clinical picture is not clear.

Paper Details

Date Published: 10 April 1998
PDF: 6 pages
Proc. SPIE 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery, (10 April 1998); doi: 10.1117/12.307338
Show Author Affiliations
Alexander V. Vinogradov, Deltatekh Ltd. (Russia)
Alexey I. Trushin, Deltatekh Ltd. (Russia)
Pavel G. Leonov, Deltatekh Ltd. (Russia)
Michael L. Stahanov, Ministry of Railway Transport (Russia)

Published in SPIE Proceedings Vol. 3259:
Systems and Technologies for Clinical Diagnostics and Drug Discovery
Gerald E. Cohn; John C. Owicki, Editor(s)

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