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Proceedings Paper

Minimally invasive and ex-vivo diagnostics of breast cancer tissues by fiber optic evanescent-wave Fourier transform IR (FEW-FTIR) spectroscopy
Author(s): Natalia I. Afanasyeva; Sergei F. Kolyakov; Vjacheslav G. Artioushenko; Victor V. Sokolov; George A. Frank
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Paper Abstract

Fourier transform IR fiberoptic evanescent wave spectroscopy has been suggested as a powerful tool for clinical diagnostics of normal, precancerous, and cancerous breast tissue ex vivo and in vitro in the middle IR region of the spectrum. This method is suitable for noninvasive and direct measurements of the spectra of normal and pathological tissues in vitro, ex vivo and in vivo. For the first time this method has been used nondestructively, rapidly, fast and remotely in the operating rooms of clinics. The aim of our studies has been the express testing of various tumor tissues during surgery to optimize and localize an area of removing tissue. We measured very small samples of normal and malignant breast tissue ex vivo with a fiber bent to a special angle, forming a special tip probe configuration. We also suggest her the minimally invasive FTIR-FEW diagnosis tool using 'needle' changeable tip probe for biopsy applications. The spectral histopathology branching could be developed with help of this technique in vitro. The breast tissue at different stages of tumor or cancer has been distinguished very clearly in spectra of amide, cyclic and noncyclic hydrogen bonded fragments, phosphate groups and sugars.

Paper Details

Date Published: 16 April 1998
PDF: 8 pages
Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); doi: 10.1117/12.305383
Show Author Affiliations
Natalia I. Afanasyeva, Univ. of Nevada/Reno and Institute of Spectroscopy (United States)
Sergei F. Kolyakov, Institute of Spectroscopy (Russia)
Vjacheslav G. Artioushenko, General Physics Institute (Germany)
Victor V. Sokolov, Herzen Oncological Research Institute (Russia)
George A. Frank, Herzen Oncological Research Institute (Russia)

Published in SPIE Proceedings Vol. 3250:
Optical Biopsy II
Robert R. Alfano, Editor(s)

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