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Proceedings Paper

Optical fluorescence and Raman biopsy of squamous cell carcinoma from the head and neck
Author(s): Yuanlong Yang; C. H. Liu; Howard E. Savage; Stimson P. Schantz M.D.; Robert R. Alfano
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Paper Abstract

Fluorescence, excitation, diffuse reflectance and FT-IR Raman spectral scans of squamous cell carcinoma of the head and neck have been studied. Eleven specimens of squamous cell carcinoma in larynx, lymph node, throat, grand, soft palate and epiglotts and nine corresponding normal specimens was tested. The excitation spectral differences between squamous cell carcinoma and normal were investigated in the protein spectral range 260 nm to 300 nm. The ratios intensity at various excitation wavelengths were used as criterion to separate carcinoma and normal tissues. The t- test of these parameter have been made. The P values of all these three parameters are less than 0.005. The statistical results of sensitivity and specificity of using three parameters compared to pathological results are about 90 percent. The Raman spectroscopy was measured. Characteristics vibrational modes were used to separate out carcinoma and correlated with excitation spectroscopy data.

Paper Details

Date Published: 16 April 1998
PDF: 4 pages
Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); doi: 10.1117/12.305364
Show Author Affiliations
Yuanlong Yang, CUNY/City College (United States)
C. H. Liu, CUNY/City College (United States)
Howard E. Savage, Memorial Sloan-Kettering Cancer Ctr. (United States)
Stimson P. Schantz M.D., Memorial Sloan-Kettering Cancer Ctr. (United States)
Robert R. Alfano, CUNY/City College (United States)

Published in SPIE Proceedings Vol. 3250:
Optical Biopsy II
Robert R. Alfano, Editor(s)

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