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Proceedings Paper

Fluorescence ratio mapping system for tissue diagnosis
Author(s): Alvin Katz; Howard E. Savage; Fanan Zeng; Jayson Rone; Gui Chen Tang; D. Harris; Jason A. Koutcher M.D.; Stimson P. Schantz M.D.; Robert R. Alfano
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Paper Abstract

A real time fluorescence ratio mapping a system for evaluating the surface of tissue can detect changes in tissue state including precancerous conditions. This system, using a personal computer and video camera, functions in near real-time, displaying pseudo color fluorescence intensity ratios maps at 15 frames per second. A fluorescence ratio mapping system functioning at close to video rates can be integrated with an endoscope to give the physician additional information during a patient exam about the state of a tissue. Preliminary measurements on ex vivo samples differentiated tumor from normal regions of tissues. Fluorescence spectral ratio maps give more structural detail of tissue than direct white light viewing. Tissue structure was observed in the fluorescence images. These results were correlated with histology.

Paper Details

Date Published: 16 April 1998
PDF: 4 pages
Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); doi: 10.1117/12.305363
Show Author Affiliations
Alvin Katz, CUNY/City College (United States)
Howard E. Savage, Memorial Sloan-Kettering Cancer Ctr. (United States)
Fanan Zeng, CUNY/City College (United States)
Jayson Rone, CUNY/City College (United States)
Gui Chen Tang, CUNY/City College (United States)
D. Harris, Memorial Sloan-Kettering Cancer Ctr. (United States)
Jason A. Koutcher M.D., Memorial Sloan-Kettering Cancer Ctr. (United States)
Stimson P. Schantz M.D., Memorial Sloan-Kettering Cancer Ctr. (United States)
Robert R. Alfano, CUNY/City College (United States)

Published in SPIE Proceedings Vol. 3250:
Optical Biopsy II
Robert R. Alfano, Editor(s)

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