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Proceedings Paper

Prostate thermal therapy with interstitial and transurethral ultrasound applicators: a feasibility study
Author(s): Chris J. Diederich; William H. Nau; Dana L. Deardorff; Ismail S. Khalil-Bustany; Everette C. Burdette; Paul R. Stauffer; Max C. Wu
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Paper Abstract

The purpose of this study was to determine the feasibility of using a transurethral ultrasound applicator in combination with implantable ultrasound applicators for inducing thermal coagulation and necrosis of localized cancer lesions or BPH within the prostate gland. The concept being evaluated is the potential to treat target zones in the anterior and lateral portions of the prostate with the transurethral applicator, while simultaneously treating regions of extracapsular extension and zones in the posterior prostate with the directive implantable applicators in combination with a rectal cooling bolus. Biothermal computer simulations, acoustic characterizations, and in vivo thermal dosimetry experiments were used to evaluate the performance of each applicator type and combinations thereof. The preliminary results of this investigation demonstrate that implantable ultrasound applicators, in combination with a transurethral ultrasound applicator, have the potential to provide thermal coagulation and necrosis of small or large regions within the prostate gland, while sparing thermally sensitive rectal tissue.

Paper Details

Date Published: 2 April 1998
PDF: 11 pages
Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998);
Show Author Affiliations
Chris J. Diederich, Univ. of California/San Francisco (United States)
William H. Nau, Univ. of California/San Francisco (United States)
Dana L. Deardorff, Univ. of California/San Francisco (United States)
Ismail S. Khalil-Bustany, Univ. of California/San Francisco (United States)
Everette C. Burdette, Acoustic MedSystems (United States)
Paul R. Stauffer, Univ. of California/San Francisco (United States)
Max C. Wu, Univ. of California/San Francisco (United States)

Published in SPIE Proceedings Vol. 3249:
Surgical Applications of Energy
Thomas P. Ryan, Editor(s)

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