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Proceedings Paper

Quantitative near-infrared spectroscopy on patients with peripheral vascular disease
Author(s): Maria-Angela Franceschini; Sergio Fantini; Renato Palumbo; Leonella Pasqualini; Gaetano Vaudo; Edoardo Franceschini; Enrico Gratton; Barbara Palumbo; Salvatore Innocente; Elmo Mannarino
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Paper Abstract

We have used near-infrared spectroscopy to measure the hemoglobin saturation at rest and during exercise on patients affected by peripheral vascular disease (PVD). The instrument used in our study is a frequency-domain tissue oximeter which employs intensity modulated (110 MHz) laser diodes. We examined 9 subjects, 3 of which were controls and 6 were patients affected by stage II PVD. The optical probe was located on the calf muscle of the subjects. The measurement protocol consisted of: (1) baseline (approximately 5 min); (2) stationary bicycle exercise (approximately 5 min); (3) recovery (approximately 15 min). The change in hemoglobin saturation during exercise ((Delta) Y) and the recovery time after exercise (trec) were significantly greater in the PVD patients ((Delta) Y equals -21 +/- 3%, trec equals 5.9 +/- 3.8 min) than in the control subjects ((Delta) Y equals 2 +/- 3%, trec equals 0.6 +/- 0.1 min).

Paper Details

Date Published: 1 January 1998
PDF: 4 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301041
Show Author Affiliations
Maria-Angela Franceschini, Univ. of Illinois/Urbana-Champaign (United States)
Sergio Fantini, Univ. of Illinois/Urbana-Champaign (United States)
Renato Palumbo, Univ. of Perugia (Italy)
Leonella Pasqualini, Policlinico Monteluce (Italy)
Gaetano Vaudo, Policlinico Monteluce (Italy)
Edoardo Franceschini, Univ. of Perugia (United States)
Enrico Gratton, Univ. of Illinois/Urbana-Champaign (United States)
Barbara Palumbo, Policlinico Monteluce (Italy)
Salvatore Innocente, Policlinico Monteluce (Italy)
Elmo Mannarino, Policlinico Monteluce (Italy)

Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron M.D.; Britton Chance; Marco Ferrari, Editor(s)

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