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Proceedings Paper

RA diagnostics applying optical tomography in frequency-domain
Author(s): Alexander D. Klose; Viravuth Prapavat; Olaf Minet; Juergen Beuthan; Gerhard J. Mueller
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Paper Abstract

Our aim is to reconstruct the optical parameters in a slice of a finger joint phantom for further investigations about rheumatoid arthritis (RA). Therefore, we have developed a flexible NIR scanning system in order to collect amplitude and phase delay of photon density waves in frequency-domain. A cylindrical finger joint phantom was embedded in a container of Intralipid solution due to the application of an inverse method for infinite geometry. The joint phantom was investigated by a laser beam obtaining several projections. The average optical parameters of each projection was calculated. Using different reconstruction techniques, e.g. ART and SIRT with a special projection operator, we reconstructed the optical parameters in a slice. The projection operator can be heuristically described by a photon path density function of a homogeneous media with infinite geometry. Applied to an object with an unknown distribution of optical parameters it calculates the expectation value of the investigated object. The potentials and limits of these fast reconstruction methods will be presented.

Paper Details

Date Published: 13 January 1998
PDF: 11 pages
Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); doi: 10.1117/12.297920
Show Author Affiliations
Alexander D. Klose, Laser- und Medizin-Technologie gGmbH (Germany)
Viravuth Prapavat, Institut fuer Medizinische Physik und Lasermedizin/Freie Univ. Berlin (Germany)
Olaf Minet, Institut fuer Medizinische Physik und Lasermedizin/Freie Univ. Berlin (Germany)
Juergen Beuthan, Institut fuer Medizinische Physik und Lasermedizin (Germany)
Gerhard J. Mueller, Laser- und Medizin-Technologie gGmbH (Germany)

Published in SPIE Proceedings Vol. 3196:
Optical and Imaging Techniques for Biomonitoring III
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Abraham Katzir, Editor(s)

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