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Proceedings Paper

Gd-meso-tetraphenylporphyrins: synthesis, encapsulation into liposomes, and characterization of the resulting preparations
Author(s): Dmitry B. Berezin; Raymond Bonnett; Maria Africa de Madariaga; Sergio I. Molina; Margarita Mora; Maria Lluisa Sagrista; Maria Asuncion Valles
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Paper Abstract

POPC, DPPC/DMPC and POPC/OOPS liposomes containing gadolinium(III) meso-tetraphenylporphyrin and gadolinium(III) meso-tetra(4-pyridyl)porphyrin have been prepared by different techniques, their porphyrin and lipid contents have been evaluated, and the size and stability of the liposomes have been determined. The results show the influence of the method of preparation on the amount of Gd-porphyrin incorporated, and that of the lipid composition on the incorporation efficiency and stability of the Gd(III) porphyrin trapped in the liposomes, as well as the presence of strong lipid to porphyrin association at least in the case of the DPPC/DMPC liposomes.

Paper Details

Date Published: 29 December 1997
PDF: 9 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297829
Show Author Affiliations
Dmitry B. Berezin, Univ. of London (United Kingdom)
Raymond Bonnett, Univ. of London (United Kingdom)
Maria Africa de Madariaga, Univ. de Barcelona (Spain)
Sergio I. Molina, Univ. de Barcelona (Spain)
Margarita Mora, Univ. de Barcelona (Spain)
Maria Lluisa Sagrista, Univ. de Barcelona (Spain)
Maria Asuncion Valles, Univ. de Barcelona (Spain)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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