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Proceedings Paper

PDT of Barrett's esophagus: kinetics and localization of 5-aminolevulinic acid-induced porphyrin accumulation in the rat esophagus
Author(s): Jolanda van den Boogert; Richard van Hillegersberg; Adriaan B. Houtsmuller; Peter D. Siersema; Ron W. F. de Bruin; Hugo W. Tilanus
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Paper Abstract

Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA)- induced photosensibilization may be used to selectively eliminate Barrett's epithelium. To find optimal treatment parameters, the kinetics, localization and mechanism of ALA- induced protoporphyrin IX (PpIX) accumulation in rat oesophagus were studied. After a single dose of ALA (200 mg/kg i.v. or oral), porphyrin accumulation in the mucosa was 3.4 fold higher than in the muscularis, with a maximum at 3 hours after ALA administration. Enzyme measurements showed a higher ratio of PBGD:ferrochelatase in mucosa. In conclusion, the rat oesophageal mucosa can be selectively photosensitized with PpIX after a single dose of ALA, with a peak concentration at 3 hours. Selectivity may be caused by the higher PBGD:ferrochelatase ratio. This makes ALA most suitable for PDT treatment of Barrett's oesophagus.

Paper Details

Date Published: 29 December 1997
PDF: 7 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297822
Show Author Affiliations
Jolanda van den Boogert, Erasmus Univ. Hospital Dijkzigt (Netherlands)
Richard van Hillegersberg, Erasmus Univ. Hospital Dijkzigt (Netherlands)
Adriaan B. Houtsmuller, Erasmus Univ. Hospital Dijkzigt (Netherlands)
Peter D. Siersema, Erasmus Univ. Hospital Dijkzigt (Netherlands)
Ron W. F. de Bruin, Erasmus Univ. Hospital Dijkzigt (Netherlands)
Hugo W. Tilanus, Erasmus Univ. Hospital Dijkzigt (Netherlands)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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