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Proceedings Paper

Detection of numerical chromosomal abnormalities (chr. 1 and 18) before and after photodynamic therapy of human bladder carcinoma cells in vitro
Author(s): Ruediger Bachor; Ella Dumbravia Reich; Klaus Kleinschmidt; Richard E. Hautmann
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Paper Abstract

The application of nonradioactive in situ hybridization with chromosome-specific probes for cytogenetic analysis has increased significantly in recent years. In the field of photodynamic therapy (PDT) the hypothesis is that after PDT the remaining viable malignant cells are potentially metastatic cells. Therefore, we performed in vitro experiments on human bladder carcinoma cells to evaluate numerical chromosomal abnormalities before and after PDT. The possible genotoxic effect of PDT with porphycene (AamTPPn) appears to be small based on criteria such as numerical chromosomal abnormalities for chromosome 1 and 18.

Paper Details

Date Published: 29 December 1997
PDF: 10 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297814
Show Author Affiliations
Ruediger Bachor, Urologische Universitaetsklinik/Univ. Ulm (Germany)
Ella Dumbravia Reich, Urologische Universitaetsklinik/Univ. Ulm (Germany)
Klaus Kleinschmidt, Urologische Universitaetsklinik/Univ. Ulm (Germany)
Richard E. Hautmann, Urologische Universitaetsklinik/Univ. Ulm (Germany)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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