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Proceedings Paper

Phosphosubstituted phthalocyanine derivatives as effective photosensitizers for PDT
Author(s): Gennadii A. Meerovich; Eugeny A. Lukyanets; Olga A. Yuzhakova; Nadezgda L. Torshina; Victor B. Loschenov; Alexander A. Stratonnikov; Eugenia A. Kogan; Georgy N. Vorozhtsov; Andrei V. Kunetz; Yury P. Kuvshinov; Boris K. Poddubny; Anna I. Volkova; Anna M. Posypanova
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Paper Abstract

The photodynamic therapy in the spectral range 690 - 750 nm is more perspective for treatment of the deeply located tumors because the absorption of tissue has a significant minimis in this spectral range. A series of phosphosubstituted phthalocyanine derivatives were studied in vitro and in experiment on white mice. It has been shown that photodynamic therapy using these photosensitizers was very effective and induced the prominent tumor damage (necrosis, apoptosis), inhibition of its growth and stimulation of antitumor desmoplastic reaction.

Paper Details

Date Published: 29 December 1997
PDF: 5 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297804
Show Author Affiliations
Gennadii A. Meerovich, General Physics Institute (Russia)
Eugeny A. Lukyanets, Organic Intermediates and Dyes Institute (Russia)
Olga A. Yuzhakova, Organic Intermediates and Dyes Institute (Russia)
Nadezgda L. Torshina, General Physics Institute (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Alexander A. Stratonnikov, General Physics Institute (Russia)
Eugenia A. Kogan, Moscow Medical Academy (Russia)
Georgy N. Vorozhtsov, Organic Intermediates and Dyes Institute (Russia)
Andrei V. Kunetz, General Physics Institute (Russia)
Yury P. Kuvshinov, Cancer Research Ctr. (Russia)
Boris K. Poddubny, Cancer Research Ctr. (Russia)
Anna I. Volkova, General Physics Institute (Russia)
Anna M. Posypanova, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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