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Proceedings Paper

Detection of cancer by means of infrared spectroscopy
Author(s): Yitzhak Weissman; Aharon Bonstein; Tania Babushkin; Zvi Malik; Arie Ornstein
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Paper Abstract

We have measured the mid-infrared spectra of several tissues in a malignant and normal state, using the ATR sampling method. The aim of the experiments was to detect cancer signatures that were discovered earlier using other sampling methods. The ATR method is particularly attractive for medical applications because it can be used in-vivo, and because it requires minimal sample preparation. We have succeeded to detect a significant signature in only one of the five spectral bands that were examined. This signature is attributed to the PO2- symmetric stretching of the nucleic acids phosphodiester groups, and is located in the vicinity of 1082 cm-1. The signature consists of a shift in the maximum absorption peak by 3 cm-1. The measured data is in good agreement with the published data. This result can lead to real-time tumor mapping during surgery and in-vivo cancer diagnosis with fiber-optic ATR probes.

Paper Details

Date Published: 22 September 1997
PDF: 7 pages
Proc. SPIE 3110, 10th Meeting on Optical Engineering in Israel, (22 September 1997);
Show Author Affiliations
Yitzhak Weissman, Soreq Nuclear Research Ctr. (Israel)
Aharon Bonstein, Soreq Nuclear Research Ctr. (Israel)
Tania Babushkin, Bar-Ilan Univ. (Israel)
Zvi Malik, Bar-Ilan Univ. (Israel)
Arie Ornstein, Shiba Medical Ctr. (Israel)

Published in SPIE Proceedings Vol. 3110:
10th Meeting on Optical Engineering in Israel
Itzhak Shladov; Stanley R. Rotman, Editor(s)

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