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Proceedings Paper

Frequency domain fluorescence optical imaging using a finite element method
Author(s): Yaling Pei; Yuqi Yao; Feng-Bao Lin; Randall Locke Barbour
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Paper Abstract

In this paper, a reconstruction algorithm for fluorescence yield and lifetime imaging in dense scattering media is formulated and implemented. Two frequency domain radiation transport equations based on the diffusion approximation are used to model the migration of excitation and emitted photons. In the forward formulation, a finite element approach, which is specially effective for complex geometries and inhomogeneous distribution of medium properties, is adopted to obtain the required imaging operator and the simulated detector responses related to the photon fluxes on the boundary. Inverse formulation is derived based on the integral form of two diffusion equations. The technique is demonstrated by reconstructing spatial images of heterogenous fluorophore distribution and life time using simulated data obtained from homogeneous and complex (i.e., MRI breast map) media containing objects with fluorophore and with and without added noise.

Paper Details

Date Published: 18 August 1997
PDF: 12 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280243
Show Author Affiliations
Yaling Pei, Polytechnic Univ./Brooklyn (United States)
Yuqi Yao, Polytechnic Univ./Brooklyn (United States)
Feng-Bao Lin, Polytechnic Univ./Brooklyn (United States)
Randall Locke Barbour, SUNY/Brooklyn (United States)

Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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