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Proceedings Paper

Development of a fluorescence video endoscopy imaging system for the early detection of cancer in the gastrointestinal tract
Author(s): Haishan Zeng; Alan Weiss; Calum E. MacAulay; Nick MacKinnon; Richard W. Cline; Remy Dawson
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Paper Abstract

The utility of autofluorescence imaging for the early detection of lung cancer has been previously demonstrated. The aim of this work is to extend the use of real time autofluorescence imaging to the early detection of cancer of the esophagus, stomach, and colon. A prototype fluorescence imaging system was developed which produces real time video images of tissue autofluorescence. The system consist of a filtered blue light source, two intensified CCD cameras, a fiber optic endoscope, and a computer based control center. The system produces a real time pseudo color display based on images acquired from two fluorescence bands. These bands were selected based on in vivo fluorescence spectroscopic studies. The generated pseudo image clearly delineates the abnormal tissue areas for biopsy. Early cancer sties missed under conventional white light examination became visible under fluorescence imaging. A further development allows the fluorescence imaging system to be used in an alternate fashion. The system captures a fluorescence image in the green and a reflectance image in the red-near IR. Different spectral information was exploited in the two imaging modes.

Paper Details

Date Published: 16 June 1997
PDF: 6 pages
Proc. SPIE 2976, Biomedical Sensing, Imaging, and Tracking Technologies II, (16 June 1997); doi: 10.1117/12.275550
Show Author Affiliations
Haishan Zeng, British Columbia Cancer Research Ctr. (Canada)
Alan Weiss, B.C. Cancer Agency (Canada)
Calum E. MacAulay, British Columbia Cancer Research Ctr. (Canada)
Nick MacKinnon, British Columbia Cancer Research Ctr. (Canada)
Richard W. Cline, Xillix Technologies Corp. (Canada)
Remy Dawson, Xillix Technologies Corp. (Canada)

Published in SPIE Proceedings Vol. 2976:
Biomedical Sensing, Imaging, and Tracking Technologies II
Tuan Vo-Dinh; Robert A. Lieberman; Gerald G. Vurek; Abraham Katzir, Editor(s)

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