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Proceedings Paper

Plasma-mediated ablation of biological tissue with picosecond and femtosecond laser pulses
Author(s): Ron M. Kurtz M.D.; Victor Elner M.D.; Xinbing Liu; Tibor Juhasz; Frieder H. Loesel; Christopher Horvath; Markolf H. Niemz; Frank Noack
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Paper Abstract

We investigated plasma-mediated surface ablation in corneal tissue using picosecond and femtosecond laser pulses in order to achieve high precision, non-thermal tissue removal with a non-ultraviolet laser source. Experiments utilized three laser systems, a regeneratively amplified Ti:sapphire laser, a synchronously amplified dye laser, and a regeneratively amplified picosecond Nd:YLF laser. Tissue ablation was performed by tightly focusing the laser beam on the tissue surface. Ablation thresholds were determined by monitoring the plasma spark, as well as the tissue surface. Tissue ablations were then analyzed by standard histologic methods and scanning electron microscopy. We observed a decrease in the ablation fluence threshold as the pulse duration is shortened from 200 ps to approximately 140 fs, in agreement with our theoretical predictions. Using identical pulse energies, the femtosecond laser pulses ablated tissue at higher efficiencies than the picosecond laser, with an approximately two-fold improvement in the etch depth curve. Histologic analysis reveal minimal adjacent tissue damage at either pulse duration. Femtosecond laser pulses may offer advantages that make them ideal tools for high precision tissue ablation.

Paper Details

Date Published: 16 June 1997
PDF: 9 pages
Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); doi: 10.1117/12.275507
Show Author Affiliations
Ron M. Kurtz M.D., Kellogg Eye Ctr./Univ. of Michigan and Univ. of Mic (United States)
Victor Elner M.D., Kellogg Eye Ctr./Univ. of Michigan and Univ. of Michiga (United States)
Xinbing Liu, Kellogg Eye Ctr./Univ. of Michigan and Univ. of Michigan (United States)
Tibor Juhasz, Kellogg Eye Ctr./Univ. of Michigan and Univ. of Michigan (United States)
Frieder H. Loesel, Univ. of Heidelberg (Germany)
Christopher Horvath, Univ. of Heidelberg (United States)
Markolf H. Niemz, Univ. of Heidelberg (Germany)
Frank Noack, Univ. of Heidelberg (Germany)

Published in SPIE Proceedings Vol. 2975:
Laser-Tissue Interaction VIII
Steven L. Jacques, Editor(s)

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