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Proceedings Paper

Laser-tissue photobiological interaction: a new mechanism for laser sensitizer immunoadjuvant treatment of metastatic cancers
Author(s): Wei R. Chen; David A. Okrongly; Robert L. Adams; Robert E. Nordquist
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Paper Abstract

Photophysical reactions have been the focus of laser-tissue interactions. However, these interactions usually have localized and short-term effect, hence only resulting in limited success against systemic lesions, especially against metastatic tumors. Could laser induce a photobiological reaction, specifically a long-term reaction in cancer treatment. Our experimental results on treatment of rat breast cancer indicated that a systemic and long term response against the tumors could be stimulated by a new laser-sensitizer-immunoadjuvant treatment. Long term impact of our method was observed; survival tumor rats and apparent ability against tumor re-challenge. The long term effect was also confirmed by our histochemical studies. Our results pointed to a humoral immune response. A new mechanism of laser-tissue interaction, namely laser-sensitizer- immunoadjuvant induced photobiological reaction, may prove to be crucial in laser cancer treatment.

Paper Details

Date Published: 16 June 1997
PDF: 8 pages
Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); doi: 10.1117/12.275492
Show Author Affiliations
Wei R. Chen, Oklahoma School of Science and Mathematics and Univ. of Oklahoma (United States)
David A. Okrongly, Xytronyx, Inc. (United States)
Robert L. Adams, Dean A. McGee Eye Institute and Univ. of Oklahoma Medical School (United States)
Robert E. Nordquist, Wound Healing of Oklahoma, Inc. (United States)

Published in SPIE Proceedings Vol. 2975:
Laser-Tissue Interaction VIII
Steven L. Jacques, Editor(s)

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