Share Email Print
cover

Proceedings Paper

In vivo argon laser vascular welding using thermal feedback: open- and closed-loop patency and collagen crosslinking
Author(s): Ward Small IV; Peter M. Celliers; George E. Kopchok M.D.; Karen M. Reiser; Nicholas J. Heredia; Duncan J. Maitland; David C. Eder; Richard A. London; Mauricio Heilbron; Farabi Hussain; Rodney A. White M.D.; Luiz Barroca Da Silva; Dennis L. Matthews
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

Paper Details

Date Published: 22 May 1997
PDF: 5 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275050
Show Author Affiliations
Ward Small IV, Lawrence Livermore National Lab. (United States)
Peter M. Celliers, Lawrence Livermore National Lab. (United States)
George E. Kopchok M.D., Harbor-UCLA Medical Ctr. (United States)
Karen M. Reiser, Univ. of California/Davis School of Medicine (United States)
Nicholas J. Heredia, Lawrence Livermore National Lab. (United States)
Duncan J. Maitland, Lawrence Livermore National Lab. (United States)
David C. Eder, Lawrence Livermore National Lab. (United States)
Richard A. London, Lawrence Livermore National Lab. (United States)
Mauricio Heilbron, Harbor-UCLA Medical Ctr. (United States)
Farabi Hussain, Harbor-UCLA Medical Ctr. (United States)
Rodney A. White M.D., Harbor-UCLA Medical Ctr. (United States)
Luiz Barroca Da Silva, Lawrence Livermore National Lab. (United States)
Dennis L. Matthews, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson M.D.; Harvey Lui M.D.; Michail M. Pankratov; Kenneth Eugene Bartels D.V.M.; Gerhard J. Mueller; Graham M. Watson M.D.; Reza S. Malek M.D.; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Lawrence S. Bass M.D.; Aaron P. Perlmutter M.D.; Kenton W. Gregory M.D.; David M. Harris; David M. Harris; Harvey Lui M.D.; Reza S. Malek M.D.; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Graham M. Watson M.D., Editor(s)

© SPIE. Terms of Use
Back to Top