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Proceedings Paper

Interstitial laser and chemotherapy combined for treatment of human squamous cell carcinoma
Author(s): Romaine E. Saxton; Ines P. Graeber; Michael J. Suh; Woo H. Paek; Marcos B. Paiva; Dan J. Castro
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Paper Abstract

We have tested a combined treatment for squamous cell carcinoma based on laser activation of anti-cancer drugs in human solid tumors. Cisplatinum and the new anthrapyrazole CI- 941 are reported to interact with photothermal energy. Combined intratumor drug and interstitial laser therapy were tested in nude mice bearing human squamous cell carcinomas grown as subcutaneous tumors. Cisplatinum injection (1.2 mg/500 mg tumor) 4 hours before KTP laser fiberoptic treatment (532 nm, 0.8 W, 10 sec/site, 300 J) resulted in complete tumor regression in 6/8 animals, while intratumor drug alone led to partial regression and tumor regrowth in 10/10 mice during 12 weeks followup. Laser treatment alone resulted in ablation followed by recurrence in 7/8 cases. Similar laser treatment 4 hours after injection of the light sensitive anthrapyrazole CI-941 led to complete tumor regression in 15/22 cases. CI-941 alone at drug levels up to 1.2 mg/gm tumor in 30 mice induced stasis followed by progression in all cases. Finally, tumor retention of 14C-CI-941 in mice 4 hrs after intralesional injection was 200-fold higher than via the systemic route and by 24 hrs remained 40-fold higher, but drug levels in normal tissues were reduced 10 - 100 fold. The data suggest laser chemotherapy may be a useful new treatment for human cancer.

Paper Details

Date Published: 22 May 1997
PDF: 8 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275040
Show Author Affiliations
Romaine E. Saxton, UCLA School of Medicine (United States)
Ines P. Graeber, Freie Univ. Berlin (Germany)
Michael J. Suh, Chicago Medical School (United States)
Woo H. Paek, UCLA School of Medicine (United States)
Marcos B. Paiva, UCLA School of Medicine (United States)
Dan J. Castro, UCLA School of Medicine (United States)

Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson M.D.; Harvey Lui M.D.; Michail M. Pankratov; Kenneth Eugene Bartels D.V.M.; Gerhard J. Mueller; Graham M. Watson M.D.; Reza S. Malek M.D.; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Lawrence S. Bass M.D.; Aaron P. Perlmutter M.D.; Kenton W. Gregory M.D.; David M. Harris; David M. Harris; Harvey Lui M.D.; Reza S. Malek M.D.; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Graham M. Watson M.D., Editor(s)

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