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Proceedings Paper

Bio-speckle method for retinal blood flow analysis: flexible correlation measurements
Author(s): Yoshihisa Aizu; Toshimitsu Asakura; Atsushi Kojima
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Paper Abstract

Bio-speckle flowmetry is useful for measuring the blood flow velocity in human retinal vessels, but it often suffers rom eye-movement artifacts and other external moving factors. To solve this problem, we studied in this paper here a flexible correlation-analyzing system which is able to extract effectively the blood flow information from erroneous data influenced by a displacement of the measuring point. On the basis of the photon correlation technique, the system directly stores the sequential counts of photo-electron pulses into the memory. After a measurement, the stored data are read out and used to calculate the first-order statistics of time-integrated speckle fluctuations and the autocorrelation function with an arbitrary delay-time unit for an arbitrary period. These results are used to specify the displacement of the measuring point due to eye movements and to eliminate erroneous data. The usefulness of this technique was verified for a glass capillary model and human retinal vessels.

Paper Details

Date Published: 2 May 1997
PDF: 12 pages
Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); doi: 10.1117/12.273603
Show Author Affiliations
Yoshihisa Aizu, Muroran Institute of Technology (Japan)
Toshimitsu Asakura, Hokkaido Univ. (Japan)
Atsushi Kojima, Kowa Company Ltd. (Japan)

Published in SPIE Proceedings Vol. 2982:
Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology
Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Robert C. Leif, Editor(s)

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