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Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e6 photosensitized death of Ehrlich carcinoma cells
Author(s): V. Chekulayev; Igor Shevchuk; Anne Kahru; Virgo Th. Mihkelsoo; A. P. Kallikorm
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Paper Abstract

The photodvnmtc prooerttes o+ e trtmetnvi ester(Eá methyl pheophorbid a (MPh) and pheophvtin a (Ph) in Ehrllch carcinoma cells were investigatea ooth in vitro ana in vivo. Mu above mentioned ohotoseneitizere(PS) induced the hotoirradiated death o4 neoolaem cciii. There was an inverse relationshlo between the hvdroDhobictty of the PS and ite ohotodvnamic activity Uess hvbroahobic Eó was shown to be most eF4ective PSI'. ccoraina to our data irradiation of Ehrlici, carcinoma cefle in the oresence of E. causea a aramatic aecrease in ATP level. The latter could be connected with suporession of the intensity of anaerobic glvcolvsis ana conEumDtion of oxygen. It could be supposeb that a decrease in AlP level in Ehrlich carcinoma cells is mainly due to th irncouplinç of OxIdiitive phophory1aition. At the same time. upp1ementrv addition of doxorubicin a chemical decreaging thea functional activity of mitochondria) to E increased both in vitro and in vivo of phototoc i ci ty of Eo. The key rol e of an enerceti c status of tumour cells in their resistance to the photodynamic action is proposed.

Paper Details

Date Published: 1 June 1991
PDF: 11 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.27129
Show Author Affiliations
V. Chekulayev, Institute of Chemistry (Estonia)
Igor Shevchuk, Institute of Chemistry (Estonia)
Anne Kahru, Institute of Chemical Physics and Biophysics (Estonia)
Virgo Th. Mihkelsoo, Tartu Univ. (Estonia)
A. P. Kallikorm, Tartu Univ. (Estonia)

Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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