For many different optical applications in medical diagnosis, like optical biopsy or optical tomography, it is important to know about the local varying optical tissue parameters. Only the knowledge of these parameters (mu) _a, (mu) _s' allows a proper interpretation of particular fluorescence or scattering intensities. THe research presented here deals with basic investigations about the extraction of optical parameters in the first cell layers from the tissue surface down to the depth of some millimeters. The paper includes results from fiberbased measurements with Intralipid20 phantoms in infinite and semi-infinite geometry and a discussion about the possibilities to develop a flying-spot scanner. This frequency domain scanning device is under construction. It can be applied within the validity range of the diffusion approximation and provides a full (mu) _a and (mu) _s detection possibility in a 2D, non-contract mapping mode.

Date Published: 6 December 1996
PDF: 11 pages
Proc. SPIE 2925, Photon Propagation in Tissues II, (6 December 1996); doi: 10.1117/12.260828

Published in SPIE Proceedings Vol. 2925:
Photon Propagation in Tissues II
David A. Benaron M.D.; Britton Chance; Gerhard J. Mueller, Editor(s)