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Proceedings Paper

Aggregation and hemolysis of human erythrocytes at photodynamic therapy
Author(s): Alexander V. Priezzhev; Nikolai N. Firsov; Eugeny Ph. Stranadko; Olga M. Ryaboshapka; Tatyana V. Chichuk; O. V. Suschinskaya
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Paper Abstract

The goal of this work is to comparatively study the side effect PDT on blood with the use of two Russian photosensitizers -- photohem and photosense. These effects were studied at in vitro and in vivo conditions. The technique of backscattering nephelometry was used to measure the parameters of aggregation kinetics and the strength of aggregates of whole blood erythrocytes. The conventional method of absorption spectrophotometry was used to monitor the level of erythrocytes hemolysis. It was shown that sensitization of blood leads to the rise of the characteristic time of Rouleax formation, of the strength of aggregates, and of the level of hemolysis. The revealed tendency to increased strength of aggregates and level of hemolysis as a result of photodynamic action can be considered as a side effect of PDT.

Paper Details

Date Published: 4 December 1996
PDF: 7 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260773
Show Author Affiliations
Alexander V. Priezzhev, Moscow State Univ. (Russia)
Nikolai N. Firsov, Russian State Medical Univ. (Russia)
Eugeny Ph. Stranadko, State Research Ctr. for Laser Medicine (Russia)
Olga M. Ryaboshapka, Moscow State Univ. (Russia)
Tatyana V. Chichuk, State Research Ctr. for Laser Medicine (Russia)
O. V. Suschinskaya, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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