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Proceedings Paper

How many molecules of a photosensitizer are necessary to photosensitize a tumor cell?
Author(s): Joerg G. Moser; Franz-Peter Montforts; Dirk Kusch; Anja Vervoorts; Dieter Kirsch; Michael Berghahn; Nermin Akguen; Angelika C. Rueck; Sonja Andrees; Birgit Wagner
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Paper Abstract

Diglycosylated porphyrinoids were shown to stack at the outer cell membrane of tumor cells in vitro. Similar phototoxicities are acquired as with the non-glycosylated drugs at amounts of only 1% of that normally taken up of the non-glycosylated drugs. This means that a strict positioning of sensitizers at sensitive compartments may reduce the amount of sensitizer necessary to sensitize a tumor cell to about 106 molecules per cell. Similar numbers were seen only in erythrocytes and with immunoconjugates in ovarian cancer. This low amount facilitates photosensitizer transport against intratumoral pressure gradients.

Paper Details

Date Published: 4 December 1996
PDF: 9 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260749
Show Author Affiliations
Joerg G. Moser, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Franz-Peter Montforts, Univ. of Bremen (Germany)
Dirk Kusch, Univ. of Bremen (Germany)
Anja Vervoorts, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Dieter Kirsch, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Michael Berghahn, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Nermin Akguen, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. of Ulm (Germany)
Angelika C. Rueck, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Sonja Andrees, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Birgit Wagner, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)

Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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